Droplet-based, Digital, Centrifugal Microfluidics

Droplet-based digital microfluidics is a topic with growing relevance to biological, chemical, and health-science fields. The high precision and excellent reagent economy of such systems are unparalleled. There are, however, fundamental challenges related to actuation and sensing in terms of system scalability, and these challenges are addressed within this chapter. In particular, a new digital microfluidics multiplexer is shown to overcome contemporary on-chip micro drop motion addressability issues and eliminate droplet interference challenges. At the same time, an integrated folded-cavity optical sensor provides highly localized and sensitive probing of internal fluid refractive indices. The complete system offers improved micro drop motion and sensing capabilities for future lab-on-a-chip technologies.

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