Micro-chemistry & Micro-systems

Micro-total analysis systems, or the so-called "Lab-on-a-chip", have attracted increasing attention because of their ability to integrate multiple biochemical processes at pL/nL-scale in a single device using microfabrication technology. The advantages of miniaturising and integrating genetic analysis include high speed, less reagent consumption, and a reduction in size of instruments. The development of microsystems or "Lab-on-a-Chip" for both biological and chemical applications is a fast growing field due to the ability of these devices to perform a complex set of successive operations at a scale not easily handled by human experimenter. If few of these systems have reached the market nowadays, there are many public and industrial researchers working together on worldwide research programs. In this paper we first present the two microsystem archetypes, the microarrays and the microfluidic systems and some of their applications in chemistry and biology (chemical microarrays, chemical microreactors, DNA chips, microseparation).

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